Skyhunter is a serious upgrade for Rogue players running Rapid Fire or Penetrating Shot. Its guaranteed critical strike effect can make a noticeable difference, especially when your build already has strong vulnerable-damage support. The quickest route is not one single activity, though. You will get better results by preparing bow materials, arranging repeatable boss runs, and keeping your crafting resources moving through the D4 items market when your own stock runs thin.

Build War Plans Around Repeat Runs
War Plans should be your first priority because they reduce the dead time between activities. Set up a chain of five endgame tasks that you can clear comfortably, rather than filling the plan with slow objectives. The reward you want is a steady supply of Lair Keys. These keys open the reward chests tied to Lord Zir, so the more smoothly your playlist runs, the more often you can return to the boss.

Choose activities close to your current travel route.
Keep the difficulty high enough for useful rewards, but not so high that clears become sluggish.
Spend surplus Lair Keys in batches instead of making one trip at a time.
Make Lord Zir the Main Target
Lord Zir remains the clearest target for Skyhunter because the bow is included in his dedicated loot pool. His arena, the Ancient Seat, is reached through The Darkened Way in the Fractured Peaks. Once your keys and boss materials are ready, run several attempts together. This feels much better than stopping after each kill to restock. Skyhunter may not appear immediately, so judge the session by the number of completed attempts rather than one lucky chest.

Method What You Need Best Use
Lord Zir Lair Keys and boss access Primary target farming
Amalgamation Five Exquisite Blood Extra rolls from Zir's pool
Bow upgrade Common bows and Cube materials Supplementary crafting
Turn Exquisite Blood Into Extra Attempts
The Horadric Cube gives you another way to use Lord Zir materials. After unlocking it during the Lord of Hatred campaign, visit the Cube in Temis and select the Amalgamation recipe. Five Exquisite Blood can be combined for a roll from Lord Zir's associated Unique pool. It does not replace the boss, but it lets you use materials that might otherwise sit in your stash. That matters during a long farming session, when every extra roll helps.

Use Spare Bows Wisely
Common white-quality bows can also be upgraded through the Cube for a chance at a Unique bow. The result is broader than a direct Skyhunter target, so treat this as a side method. Spend Obols at the Purveyor of Curiosities to gather more bows, and check unwanted Ancestral equipment for materials that can be processed. A simple routine works well: run War Plans, defeat Lord Zir, spend Exquisite Blood, then use spare bows before returning to town. With that loop in place, you can keep chasing Skyhunter while making practical use of D4 items buy options when your supplies need a quick top-up.

Hunting Skyhunter for a Diablo 4 Rogue build? Keep an eye on current in-game boss loot tables, save your materials for focused runs, and don't let a dry streak ruin the fun. For players comparing Diablo 4 item options between sessions, U4GM is worth a look at https://www.u4gm.com/diablo-4/items before you jump back into Rapid Fire or Penetrating Shot farming.