After giving my dog her first dose of Frontline, three days later she broke out in a rash and I brought her to the vet. He said she had a skin infection. She was treated with antibotics. I said that it happened right after the application and was told that they were not related. The following month I once again applied Frontline Plus. The following week the dog once again broke out and was put on antibotics. With in 2 weeks the dog began having seizure like symptons. Was tested and she was found to be anemic. Treatments did not work and she died on 3/22/10.

This was a very healthy dog with absolutely no problems at all. She was taken to the vet on a regular basis. Within 6 weeks of her first application she went from a playful part of our family to dead. She was 25lbs when we gave her the first treatment and was 18 pounds when she died.