How does radiofrequency ablation work for cancer? Radiofrequency ablation works by passing electrical currents in the range of radiofrequency waves between the needle electrode and the grounding pads placed on the patient's skin. These currents create heat around the electrode. The heat is directed into the tumor where it heats and destroys the cancer cells. Radiofrequency ablation for cancer is a minimally invasive procedure that uses electrical energy and heat to destroy cancer cells. The radiologist uses imaging tests to guide a thin... read full review »